Partial reversal of increased preproenkephalin messenger ribonucleic acid (mRNA) and decreased preprotachykinin mRNA by foetal dopamine cells in unilateral 6‐Hydroxydopamine–Lesioned rat striatum parallels functional recovery
Identifieur interne : 005599 ( Main/Exploration ); précédent : 005598; suivant : 005600Partial reversal of increased preproenkephalin messenger ribonucleic acid (mRNA) and decreased preprotachykinin mRNA by foetal dopamine cells in unilateral 6‐Hydroxydopamine–Lesioned rat striatum parallels functional recovery
Auteurs : B. Zeng [Royaume-Uni] ; Jenner [Royaume-Uni] ; C. D. Marsden [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1996-01.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- 6‐Hydroxydopamine lesion, Animal, Animal model, Animals, Brain Tissue Transplantation (physiology), Corpus Striatum (drug effects), Corpus Striatum (physiology), Corpus striatum, Dominance, Cerebral (drug effects), Dominance, Cerebral (physiology), Dopamine (physiology), Enkephalins (genetics), Exploration, Female, Fetal Tissue Transplantation (physiology), Focal lesion, Foetal dopamine neurone graft, Gene Expression (drug effects), Gene Expression (physiology), Gene expression, Immunohistochemistry, In situ, Male, Mesencephalon (transplantation), Messenger RNA, Molecular hybridization, Nerve Regeneration (drug effects), Nerve Regeneration (genetics), Oxidopamine (pharmacology), Preproenkephalin, Preproenkephalin messenger ribonucleic acid, Preprotachykinin messenger ribonucleic acid, Protein Precursors (genetics), RNA, Messenger (genetics), Rat, Rats, Rats, Wistar, Stereotyped Behavior (drug effects), Stereotyped Behavior (physiology), Substantia Nigra (drug effects), Substantia Nigra (physiology), Tachykinins (genetics).
- MESH :
- chemical , genetics : Enkephalins, Protein Precursors, RNA, Messenger, Tachykinins.
- chemical , pharmacology : Oxidopamine.
- chemical , physiology : Dopamine.
- drug effects : Corpus Striatum, Dominance, Cerebral, Gene Expression, Nerve Regeneration, Stereotyped Behavior, Substantia Nigra.
- genetics : Nerve Regeneration.
- physiology : Brain Tissue Transplantation, Corpus Striatum, Dominance, Cerebral, Fetal Tissue Transplantation, Gene Expression, Stereotyped Behavior, Substantia Nigra.
- transplantation : Mesencephalon.
- Animals, Female, Male, Rats, Rats, Wistar.
Abstract
In situ hybridization histochemistry was used to investigate the expression of striatal preproenkephalin and preprotachykinin messenger ribonucleic acid (mRNA) in rats with 6‐hydroxydopamine lesions of the nigrostriatal pathway followed 4 weeks later by implantation of foetal dopamine cells into the denervated striatum. Striatal dopamine deafferentation caused an (+)‐amphetamine‐induced rotational asymmetry, an increase in striatal preproenkephalin mRNA message, and a decrease in striatal preprotachykinin mRNA message relative to control animals. Two months after grafting a foetal ventral mesencephalon suspension, there was reversal of the rotational asymmetry to (+)‐amphetamine. At this time the increase in striatal preproenkephalin mRNA was significantly attenuated and the decrease in preprotachykinin mRNA was partially reversed compared to animals with a 6‐hydroxydopamine lesion alone. Subregional analysis showed the attenuation of the increase in preproenkephalin mRNA to occur in dorsolateral, dorsomedial and ventromedial, but not ventrolateral, striatal subdivisions. The partial reversal of the decreased preprotachykinin mRNA density after grafting was only statistically significant in the DM and VM subdivisions. These results demonstrate graft‐induced partial recovery of striatal function, as judged by preproenkephalin and preprotachykinin mRNA levels, within 2 months of transplantation.
Url:
DOI: 10.1002/mds.870110109
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000917
- to stream Istex, to step Curation: 000917
- to stream Istex, to step Checkpoint: 003B01
- to stream PubMed, to step Corpus: 004888
- to stream PubMed, to step Curation: 004888
- to stream PubMed, to step Checkpoint: 004783
- to stream Ncbi, to step Merge: 004B41
- to stream Ncbi, to step Curation: 004B41
- to stream Ncbi, to step Checkpoint: 004B41
- to stream Main, to step Merge: 008705
- to stream PascalFrancis, to step Corpus: 003426
- to stream PascalFrancis, to step Curation: 003398
- to stream PascalFrancis, to step Checkpoint: 003339
- to stream Main, to step Merge: 008871
- to stream Main, to step Curation: 005599
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Partial reversal of increased preproenkephalin messenger ribonucleic acid (mRNA) and decreased preprotachykinin mRNA by foetal dopamine cells in unilateral 6‐Hydroxydopamine–Lesioned rat striatum parallels functional recovery</title><author><name sortKey="Zeng, B" sort="Zeng, B" uniqKey="Zeng B" first="B." last="Zeng">B. Zeng</name></author><author><name sortKey="Jenner" sort="Jenner" uniqKey="Jenner" last="Jenner">Jenner</name></author><author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C. D." last="Marsden">C. D. Marsden</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D2770AA2280A5523BB0599F3058175A63CBBA59B</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1002/mds.870110109</idno><idno type="url">https://api.istex.fr/document/D2770AA2280A5523BB0599F3058175A63CBBA59B/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000917</idno><idno type="wicri:Area/Istex/Curation">000917</idno><idno type="wicri:Area/Istex/Checkpoint">003B01</idno><idno type="wicri:doubleKey">0885-3185:1996:Zeng B:partial:reversal:of</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:8771066</idno><idno type="wicri:Area/PubMed/Corpus">004888</idno><idno type="wicri:Area/PubMed/Curation">004888</idno><idno type="wicri:Area/PubMed/Checkpoint">004783</idno><idno type="wicri:Area/Ncbi/Merge">004B41</idno><idno type="wicri:Area/Ncbi/Curation">004B41</idno><idno type="wicri:Area/Ncbi/Checkpoint">004B41</idno><idno type="wicri:doubleKey">0885-3185:1996:Zeng B:partial:reversal:of</idno><idno type="wicri:Area/Main/Merge">008705</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:96-0142806</idno><idno type="wicri:Area/PascalFrancis/Corpus">003426</idno><idno type="wicri:Area/PascalFrancis/Curation">003398</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">003339</idno><idno type="wicri:doubleKey">0885-3185:1996:Zeng B:partial:reversal:of</idno><idno type="wicri:Area/Main/Merge">008871</idno><idno type="wicri:Area/Main/Curation">005599</idno><idno type="wicri:Area/Main/Exploration">005599</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Partial reversal of increased preproenkephalin messenger ribonucleic acid (mRNA) and decreased preprotachykinin mRNA by foetal dopamine cells in unilateral 6‐Hydroxydopamine–Lesioned rat striatum parallels functional recovery</title><author><name sortKey="Zeng, B" sort="Zeng, B" uniqKey="Zeng B" first="B." last="Zeng">B. Zeng</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurodegenerative Disease Research Centre, Pharmacology Group, Biomedical Sciences Division, King's College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Jenner" sort="Jenner" uniqKey="Jenner" last="Jenner">Jenner</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurodegenerative Disease Research Centre, Pharmacology Group, Biomedical Sciences Division, King's College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C. D." last="Marsden">C. D. Marsden</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University Department of Clinical Neurology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1996-01">1996-01</date><biblScope unit="vol">11</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="43">43</biblScope><biblScope unit="page" to="52">52</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D2770AA2280A5523BB0599F3058175A63CBBA59B</idno><idno type="DOI">10.1002/mds.870110109</idno><idno type="ArticleID">MDS870110109</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>6‐Hydroxydopamine lesion</term><term>Animal</term><term>Animal model</term><term>Animals</term><term>Brain Tissue Transplantation (physiology)</term><term>Corpus Striatum (drug effects)</term><term>Corpus Striatum (physiology)</term><term>Corpus striatum</term><term>Dominance, Cerebral (drug effects)</term><term>Dominance, Cerebral (physiology)</term><term>Dopamine (physiology)</term><term>Enkephalins (genetics)</term><term>Exploration</term><term>Female</term><term>Fetal Tissue Transplantation (physiology)</term><term>Focal lesion</term><term>Foetal dopamine neurone graft</term><term>Gene Expression (drug effects)</term><term>Gene Expression (physiology)</term><term>Gene expression</term><term>Immunohistochemistry</term><term>In situ</term><term>Male</term><term>Mesencephalon (transplantation)</term><term>Messenger RNA</term><term>Molecular hybridization</term><term>Nerve Regeneration (drug effects)</term><term>Nerve Regeneration (genetics)</term><term>Oxidopamine (pharmacology)</term><term>Preproenkephalin</term><term>Preproenkephalin messenger ribonucleic acid</term><term>Preprotachykinin messenger ribonucleic acid</term><term>Protein Precursors (genetics)</term><term>RNA, Messenger (genetics)</term><term>Rat</term><term>Rats</term><term>Rats, Wistar</term><term>Stereotyped Behavior (drug effects)</term><term>Stereotyped Behavior (physiology)</term><term>Substantia Nigra (drug effects)</term><term>Substantia Nigra (physiology)</term><term>Tachykinins (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Enkephalins</term><term>Protein Precursors</term><term>RNA, Messenger</term><term>Tachykinins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Oxidopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Corpus Striatum</term><term>Dominance, Cerebral</term><term>Gene Expression</term><term>Nerve Regeneration</term><term>Stereotyped Behavior</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Nerve Regeneration</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brain Tissue Transplantation</term><term>Corpus Striatum</term><term>Dominance, Cerebral</term><term>Fetal Tissue Transplantation</term><term>Gene Expression</term><term>Stereotyped Behavior</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Mesencephalon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Male</term><term>Rats</term><term>Rats, Wistar</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animal</term><term>Corps strié</term><term>Exploration</term><term>Expression génique</term><term>Hybridation moléculaire</term><term>Immunohistochimie</term><term>In situ</term><term>Lésion focale</term><term>Modèle animal</term><term>Préproenképhaline</term><term>Préprotachykinine</term><term>RNA messager</term><term>Rat</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In situ hybridization histochemistry was used to investigate the expression of striatal preproenkephalin and preprotachykinin messenger ribonucleic acid (mRNA) in rats with 6‐hydroxydopamine lesions of the nigrostriatal pathway followed 4 weeks later by implantation of foetal dopamine cells into the denervated striatum. Striatal dopamine deafferentation caused an (+)‐amphetamine‐induced rotational asymmetry, an increase in striatal preproenkephalin mRNA message, and a decrease in striatal preprotachykinin mRNA message relative to control animals. Two months after grafting a foetal ventral mesencephalon suspension, there was reversal of the rotational asymmetry to (+)‐amphetamine. At this time the increase in striatal preproenkephalin mRNA was significantly attenuated and the decrease in preprotachykinin mRNA was partially reversed compared to animals with a 6‐hydroxydopamine lesion alone. Subregional analysis showed the attenuation of the increase in preproenkephalin mRNA to occur in dorsolateral, dorsomedial and ventromedial, but not ventrolateral, striatal subdivisions. The partial reversal of the decreased preprotachykinin mRNA density after grafting was only statistically significant in the DM and VM subdivisions. These results demonstrate graft‐induced partial recovery of striatal function, as judged by preproenkephalin and preprotachykinin mRNA levels, within 2 months of transplantation.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Zeng, B" sort="Zeng, B" uniqKey="Zeng B" first="B." last="Zeng">B. Zeng</name></region><name sortKey="Jenner" sort="Jenner" uniqKey="Jenner" last="Jenner">Jenner</name><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C. D." last="Marsden">C. D. Marsden</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005599 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005599 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:D2770AA2280A5523BB0599F3058175A63CBBA59B
|texte= Partial reversal of increased preproenkephalin messenger ribonucleic acid (mRNA) and decreased preprotachykinin mRNA by foetal dopamine cells in unilateral 6‐Hydroxydopamine–Lesioned rat striatum parallels functional recovery
}}
| This area was generated with Dilib version V0.6.23. |  |